https://www.37cbio.com/about daily 0.75 2026-06-28 https://images.squarespace-cdn.com/content/v1/5ce435d6bea1ed00016ba287/1558964652247-5MWXNMFZVOPGE4TY6U2Q/MHeiderich_ReflexionenZwei-05-copy.jpg About https://images.squarespace-cdn.com/content/v1/5f0350669363e644986a59f9/39314f46-0fee-4400-aa99-da5470797dd7/protein+trimer About - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5f0350669363e644986a59f9/de1507d1-41aa-418a-aea3-abc608c1f0bd/protein+ligand+complex About - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5f0350669363e644986a59f9/38c5c993-f839-4e53-94de-421c9695745d/complex.png About - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5f0350669363e644986a59f9/a86ee29c-4a9f-4e28-973c-3d7380736fde/active+compound+in+site About - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.37cbio.com/contact daily 0.75 2026-06-28 https://images.squarespace-cdn.com/content/v1/5ce435d6bea1ed00016ba287/1558964652247-5MWXNMFZVOPGE4TY6U2Q/MHeiderich_ReflexionenZwei-05-copy.jpg Contact https://www.37cbio.com/casestudies daily 0.75 2026-06-28 https://images.squarespace-cdn.com/content/v1/5f0350669363e644986a59f9/2c7a0d19-e61b-411a-aa75-8ee4ed189557/FACS+development https://images.squarespace-cdn.com/content/v1/5f0350669363e644986a59f9/36ce2b39-7024-4058-b557-c709cca3759c/heterotetrameric+receptor+ligand+complex https://images.squarespace-cdn.com/content/v1/5f0350669363e644986a59f9/16c785f2-6f48-4166-8cdf-7f7a21fb02d2/assay.png https://www.37cbio.com/home daily 1.0 2026-06-28 https://images.squarespace-cdn.com/content/v1/5f0350669363e644986a59f9/1594059193443-EZL6W3ZU0515YETYO0WG/protein+binding+a+ligand 37C consulting and lab projects - Home - Difficult proteins and custom reagents High-quality reagents: expression, purification, construct design, and QC for proteins used in crystallography, cryo-EM, biophysics, DEL/HTS, and functional assays. We also generate custom enzymes, protein conjugates, cell lines, bacterial strains, and other hard-to-source reagents. Membrane protein expertise: we produce native-like, active membrane proteins in traditional detergent micelles, protein nanodiscs, or using the cutting-edge detergent-free copolymer embedding. https://images.squarespace-cdn.com/content/v1/5f0350669363e644986a59f9/1594059033576-TUL37R6X304SH3CL4B93/complex+protein+pocket 37C consulting and lab projects - Home - Target strategy and program advisory Target evaluation & discovery strategy: literature and patent landscape analysis, competitive assessment, target validation strategy, and program design. We help teams decide what to work on and how to de-risk it. IP and scientific writing: patent/domain/prior art analysis, expert craftsmanship for white papers, investor materials, grants, etc. Program advisory and management: senior scientific input for discovery teams that need experienced judgment and project management/leadership without full-time hire - assay strategy, data interpretation, support for key go/no-go decisions. https://images.squarespace-cdn.com/content/v1/5f0350669363e644986a59f9/1594058680052-GVSKZH6Q7CAYWDNS6QXV/optimizing+strategy+for+target 37C consulting and lab projects - Home - Target Exploration and Assay Development Target assessment, design, evaluation, and optimization for DEL, HTS, or Biophysics. Site specific biotinylation, alternative immobilization and tagging techniques, thorough QC that distinguishes a usable screen from a failed one. Assay development, enzymology, de novo assay design and HT-format adaptation. Biochemical assays with difficult or unusual substrates, biophysical assays adapted to HT format, cell-based assays and more. https://images.squarespace-cdn.com/content/v1/5f0350669363e644986a59f9/1594058813324-ILP13G88QOZMZWXRFHVM/we+work+with+most+targets 37C consulting and lab projects - Home - Targets we work on Enzymes: kinases, phosphatases, proteases, deubiquitinases (DUBs), E3 ligases, methyltransferases, demethylases, acetyltransferases, deacetylases, GTPases, ATPases, polymerases, helicases Protein-protein interaction targets: cytokines and cytokine receptors, scaffold and adapter proteins, transcription factors, molecular glue and PROTAC ternary complexes, checkpoint regulators. Known challenges: membrane proteins, nucleic acid binders, intrinsically disordered proteins, large complexes - we create bespoke solutions to difficult problems. https://images.squarespace-cdn.com/content/v1/5f0350669363e644986a59f9/1594058723735-M3FKRGFUFQ2E0E8G6HFY/complex+ligand+in+active+site 37C consulting and lab projects - Home - Structure-guided, experimentally grounded Structural and mechanistic reasoning is our foundation. We use modeling, AI-assisted tools, computational chemistry, and molecular design where useful — but always tied to experiments that can test the idea.