37C Bio is a scientific services company for discovery teams working on hard biology.

We combine senior scientific judgment with hands-on experimental execution. Our work spans target evaluation, difficult proteins, custom reagents, DEL/HTS preparation, assay development, and pre-IND discovery support.

We are most useful when a project does not fit a standard CRO menu — when the protein is difficult, the assay is failing, the reagent does not exist, or the next experiment is unclear.

Please contact us for an in-depth consultation!

A word from our Founder: What makes us different:

Hands-on ownership of every project. Engagements are scoped and run by experienced scientists, not handed off after the kickoff call. The person you talk to is one of the people doing the work.

Strategy plus execution. Most consultants stop at the slide deck; most CROs start at the bench. We do both.

Built for hard problems. We take on targets, assays, reagents, and scientific questions that do not fit standard workflows, and we are direct when something is unlikely to work.

Boutique by design, selective by choice. We stay selective so we can stay technically deep, responsive, and accountable.

Our team brings together an extended network of vetted affiliate senior experts as well as several hands-on people with combined experience across 15 companies and dozens of therapeutic programs.

Based in Worcester, MA and Manchester, NH, we serve clients across the U.S. and internationally. Our wet-lab capacity supports protein production, assay development, and reagent generation at the scale appropriate for discovery-stage programs, single targets to small panels.

If you have a problem that doesn't fit a standard CRO menu — or you need senior scientific judgment without a full-time hire — we'd like to hear about it.

—-Silke Evdokimov
20+ years working with difficult proteins, discovery assays, and target biology.